Description

Antimicrobial resistance (AMR) is a major world health problem. Bacterial biofilms are difficult to treat and represent one of the mechanisms of AMR. One explanation is the poor difusivity of antimicrobials into the biofilm matrix that creates a barrier to combat the embeded bacteria. This project aims at developing a new microvector consisting of microbubbles (MB) loaded with an antibiotic. Upon ultrasonic irradiation, MB generate fluid microstreams that could disrupt the biofilm, and at the same time, release the loaded antibiotic. The synergistic action of both antimicrobial mechanisms, mechanical and chemical, has the potential to combat AMR, specifically for resistant biofilm-forming bacteria such as Staphylococcus aureus.

In this project antibiotic-loaded MBs will be synthesized, characterized and the concept of controlled release evaluated in new and in vivo models of biofilms. The project will be developed in collaboration with two lab...