The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory

Our research team is interested in the spatio-temporal regulation of the mechanisms that govern genome stability in response to perturbations to the DNA replication process. Flaws in the DNA replication process, known as replication stress (RS), is a source of genome instability contributing to genomic disorders including cancer1. The causes of replication stress are many and varied but ultimately result in stressed replication forks that are fragile DNA structures prone to chromoso...