Position and assignments

Chronic inflammatory diseases, including chronic pulmonary disorders such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis, as well as chronic wound-healing disorders such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers, are characterized by excessive neutrophilic inflammation. This persistent inflammatory state disrupts the normal protease–antiprotease balance within affected tissues, resulting in tissue damage, impaired mucus clearance, sustained inflammation, and defective immune responses. Consequently, the proteases involved in these pathological processes represent attractive therapeutic targets.

This project focuses on the development of nano-antibody-based therapeutic candidates targeting two major proteases associated with chronic inflammatory diseases. It is a highly interdisciplinary project that combines expertise in molecular biology, protein production,...